Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods

Jennifer A. White; Joshua T. Kufera; Niklas Bachmann; Weiwei Dai; Francesco R. Simonetti; Ciara Armstrong; Jun Lai; Subul Beg; Janet D. Siliciano; Robert F. Siliciano

doi:10.1371/journal.ppat.1010845

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Open Access

Peer-reviewed

Research Article

Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods

Jennifer A. White,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Joshua T. Kufera,

Roles Investigation

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Niklas Bachmann,

Roles Investigation

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Weiwei Dai,

Roles Investigation

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Francesco R. Simonetti,

Roles Investigation

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Ciara Armstrong,

Roles Investigation

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jun Lai,

Roles Investigation, Resources

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Subul Beg,

Roles Investigation, Resources

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Janet D. Siliciano,

Roles Conceptualization, Formal analysis, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Robert F. Siliciano

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: rsiliciano@jhmi.edu

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Howard Hughes Medical Institute, Baltimore, Maryland, United States of America

https://orcid.org/0000-0002-1764-1993

⨯

Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods

Jennifer A. White,
Joshua T. Kufera,
Niklas Bachmann,
Weiwei Dai,
Francesco R. Simonetti,
Ciara Armstrong,
Jun Lai,
Subul Beg,
Janet D. Siliciano,
Robert F. Siliciano

Published: September 8, 2022
https://doi.org/10.1371/journal.ppat.1010845

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