Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini

• Sujittra Chaiyadet ,

  Contributed equally to this work with: Sujittra Chaiyadet, Sirikachorn Tangkawattana, Michael J. Smout, Wannaporn Ittiprasert

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Tropical Medicine Graduate Program, Academic Affairs, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

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• Sirikachorn Tangkawattana ,

  Contributed equally to this work with: Sujittra Chaiyadet, Sirikachorn Tangkawattana, Michael J. Smout, Wannaporn Ittiprasert

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand, and WHO Collaborating Center for Research and Control of Opisthorchiasis, Tropical Disease Research Center, Khon Kaen University, Khon Kaen, Thailand

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• Michael J. Smout ,

  Contributed equally to this work with: Sujittra Chaiyadet, Sirikachorn Tangkawattana, Michael J. Smout, Wannaporn Ittiprasert

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia

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• Wannaporn Ittiprasert ,

  Contributed equally to this work with: Sujittra Chaiyadet, Sirikachorn Tangkawattana, Michael J. Smout, Wannaporn Ittiprasert

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

  Affiliation Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, District of Columbia, United States of America

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• Victoria H. Mann,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, District of Columbia, United States of America

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• Raksawan Deenonpoe,

  Roles Investigation, Methodology

  Affiliation Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

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• Patpicha Arunsan,

  Roles Conceptualization, Investigation

  Affiliations Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, District of Columbia, United States of America

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• Alex Loukas ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: alex.loukas@jcu.edu.au (AL); pbrindley@gwu.edu (PJB); thewa_la@kku.ac.th (TL)

  Affiliation Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia

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• Paul J. Brindley ,

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: alex.loukas@jcu.edu.au (AL); pbrindley@gwu.edu (PJB); thewa_la@kku.ac.th (TL)

  Affiliation Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, District of Columbia, United States of America

  https://orcid.org/0000-0003-1765-0002

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• Thewarach Laha

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: alex.loukas@jcu.edu.au (AL); pbrindley@gwu.edu (PJB); thewa_la@kku.ac.th (TL)

  Affiliation Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

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