Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

• Zhen Qin,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Aurélie Bouteau,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Christopher Herbst,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Botond Z. Igyártó

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: botond.igyarto@jefferson.edu

  Affiliation Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-9770-800X

  ⨯