The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci

• Paddy S. Gibson,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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• Evan Bexkens,

  Roles Investigation

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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• Sylvia Zuber,

  Roles Investigation

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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• Lauren A. Cowley,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Department of Biology & Biochemistry, Milner Centre for Evolution, University of Bath, Bath, United Kingdom

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• Jan-Willem Veening

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  * E-mail: Jan-Willem.Veening@unil.ch

  Affiliation Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

  https://orcid.org/0000-0002-3162-6634

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