Bet-hedging antimicrobial strategies in macrophage phagosome acidification drive the dynamics of Cryptococcus neoformans intracellular escape mechanisms

• Quigly Dragotakes,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-4068-5828

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• Ella Jacobs,

  Roles Investigation, Methodology, Visualization

  Affiliation Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-2427-6971

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• Lia Sanchez Ramirez,

  Roles Investigation

  Affiliation Department of Molecular and Cell Biology, Johns Hopkins University, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-4110-9873

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• Olivia Insun Yoon,

  Roles Investigation

  Affiliation Department of Molecular and Cell Biology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Caitlin Perez-Stable,

  Roles Investigation

  Affiliation Department of Molecular and Cell Biology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Hope Eden,

  Roles Investigation

  Affiliation Department of Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Jenlu Pagnotta,

  Roles Investigation, Visualization

  Affiliation Department of Molecular and Cell Biology, Johns Hopkins University, Baltimore, Maryland, United States of America

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• Raghav Vij,

  Roles Investigation, Visualization

  Affiliation Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

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• Aviv Bergman,

  Roles Methodology, Resources, Supervision, Validation

  Affiliations Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York City, New York, United States of America, Santa Fe Institute, Santa Fe, New Mexico, United States of America

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• Franco D’Alessio,

  Roles Methodology, Resources, Supervision, Validation

  Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States of America

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• Arturo Casadevall

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: acasade1@jhu.edu

  Affiliation Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-9402-9167

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