Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile

Leila M. Reyes Ruiz; Kathleen A. King; Christian Agosto-Burgos; Isabella S. Gamez; Nicole C. Gadda; Elizabeth M. Garrett; Rita Tamayo

doi:10.1371/journal.ppat.1010677

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Open Access

Peer-reviewed

Research Article

Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile

Leila M. Reyes Ruiz,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯
Kathleen A. King,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯
Christian Agosto-Burgos,

Roles Formal analysis, Investigation

Affiliation Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯
Isabella S. Gamez,

Roles Formal analysis, Investigation

Affiliation Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯
Nicole C. Gadda,

Roles Formal analysis, Investigation

Affiliation Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯
Elizabeth M. Garrett,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
⨯
Rita Tamayo

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

* E-mail: rita_tamayo@med.unc.edu

Affiliation Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

https://orcid.org/0000-0002-3745-3316

⨯

Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile

Leila M. Reyes Ruiz,
Kathleen A. King,
Christian Agosto-Burgos,
Isabella S. Gamez,
Nicole C. Gadda,
Elizabeth M. Garrett,
Rita Tamayo

Published: July 5, 2022
https://doi.org/10.1371/journal.ppat.1010677

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