A protein–protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity

Mengjiao Fu; Yuchen Liu; Guannan Wang; Peng Wang; Jianing Zhang; Chen Chen; Mingliang Zhao; Shan Zhang; Jun Jiao; Xuan Ouyang; Yonghui Yu; Bohai Wen; Chengzhi He; Jian Wang; Dongsheng Zhou; Xiaolu Xiong

doi:10.1371/journal.ppat.1010660

Loading metrics

Open Access

Peer-reviewed

Research Article

A protein–protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity

Mengjiao Fu,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Yuchen Liu,

Roles Formal analysis, Software, Visualization, Writing – original draft

Affiliation State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China
⨯
Guannan Wang,

Roles Investigation

Affiliation Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China
⨯
Peng Wang,

Roles Software, Visualization

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Jianing Zhang,

Roles Investigation

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Chen Chen,

Roles Methodology

Current address: Gilead Sciences, Inc., Foster City, California, United States of America

Affiliation Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
⨯
Mingliang Zhao,

Roles Formal analysis, Investigation

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Shan Zhang,

Roles Investigation

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Jun Jiao,

Roles Formal analysis, Methodology

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Xuan Ouyang,

Roles Formal analysis

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Yonghui Yu,

Roles Project administration

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Bohai Wen,

Roles Supervision, Writing – original draft

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
Chengzhi He,

Roles Resources, Software

Affiliation Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China
⨯
Jian Wang,

Roles Formal analysis, Methodology, Resources

Affiliation State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China
⨯
Dongsheng Zhou ,

Roles Project administration, Resources, Supervision

* E-mail: zhouds@bmi.ac.cn, dongshengzhou1977@gmail.com (DZ); xiongxiaolu624@sohu.com (XX)

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China
⨯
[ ... ],
Xiaolu Xiong

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft

* E-mail: zhouds@bmi.ac.cn, dongshengzhou1977@gmail.com (DZ); xiongxiaolu624@sohu.com (XX)

Affiliation State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medicine Sciences, Fengtai, Beijing,China

https://orcid.org/0000-0002-6663-6736

⨯
[ view all ]
[ view less ]

A protein–protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity

Mengjiao Fu,
Yuchen Liu,
Guannan Wang,
Peng Wang,
Jianing Zhang,
Chen Chen,
Mingliang Zhao,
Shan Zhang,
Jun Jiao,
Xuan Ouyang

Published: July 11, 2022
https://doi.org/10.1371/journal.ppat.1010660

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Coxiella burnetii
Is the Subject Area "Coxiella burnetii" applicable to this article?

Thanks for your feedback.
Proteasomes
Is the Subject Area "Proteasomes" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Spleen
Is the Subject Area "Spleen" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Host cells
Is the Subject Area "Host cells" applicable to this article?

Thanks for your feedback.
Host-pathogen interactions
Is the Subject Area "Host-pathogen interactions" applicable to this article?

Thanks for your feedback.