The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

Tiziana Ginex; Clara Marco-Marín; Miłosz Wieczór; Carlos P. Mata; James Krieger; Paula Ruiz-Rodriguez; Maria Luisa López-Redondo; Clara Francés-Gómez; Roberto Melero; Carlos Óscar Sánchez-Sorzano; Marta Martínez; Nadine Gougeard; Alicia Forcada-Nadal; Sara Zamora-Caballero; Roberto Gozalbo-Rovira; Carla Sanz-Frasquet; Rocío Arranz; Jeronimo Bravo; Vicente Rubio; Alberto Marina; The IBV-Covid19-Pipeline; Ron Geller; Iñaki Comas; Carmen Gil; Mireia Coscolla; Modesto Orozco; José Luis Llácer; Jose-Maria Carazo

doi:10.1371/journal.ppat.1010631

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Open Access

Peer-reviewed

Research Article

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

Tiziana Ginex ,

Contributed equally to this work with: Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P. Mata, James Krieger, Paula Ruiz-Rodriguez

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain
⨯
Clara Marco-Marín ,

Contributed equally to this work with: Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P. Mata, James Krieger, Paula Ruiz-Rodriguez

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain
⨯
Miłosz Wieczór ,

Contributed equally to this work with: Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P. Mata, James Krieger, Paula Ruiz-Rodriguez

Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Molecular Modeling and Bioinformatics, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain

https://orcid.org/0000-0003-4990-8629

⨯
Carlos P. Mata ,

Contributed equally to this work with: Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P. Mata, James Krieger, Paula Ruiz-Rodriguez

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

Affiliations Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain, Centro Nacional de Microbiología (CNM-ISCIII), Instituto de Salud Carlos III, Madrid, Spain
⨯
James Krieger ,

Contributed equally to this work with: Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P. Mata, James Krieger, Paula Ruiz-Rodriguez

Roles Formal analysis, Funding acquisition, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
⨯
Paula Ruiz-Rodriguez ,

Contributed equally to this work with: Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P. Mata, James Krieger, Paula Ruiz-Rodriguez

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation I2SysBio, University of Valencia-CSIC, FISABIO Joint Research Unit Infection and Public Health, Valencia, Spain
⨯
Maria Luisa López-Redondo,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain
⨯
Clara Francés-Gómez,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation I2SysBio, University of Valencia-CSIC, FISABIO Joint Research Unit Infection and Public Health, Valencia, Spain
⨯
Roberto Melero,

Roles Data curation, Formal analysis, Investigation

Affiliation Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
⨯
Carlos Óscar Sánchez-Sorzano,

Roles Data curation, Formal analysis

Affiliation Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
⨯
Marta Martínez,

Roles Data curation, Formal analysis

Affiliation Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
⨯
Nadine Gougeard,

Roles Investigation, Methodology

Affiliations Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain
⨯
Alicia Forcada-Nadal,

Roles Formal analysis, Investigation, Visualization, Writing – original draft

Affiliations Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain
⨯
Sara Zamora-Caballero,

Roles Investigation

Affiliation Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain
⨯
Roberto Gozalbo-Rovira,

Roles Formal analysis, Investigation, Visualization

Affiliation Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain
⨯
Carla Sanz-Frasquet,

Roles Investigation

Affiliation Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain
⨯
Rocío Arranz,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
⨯
Jeronimo Bravo,

Roles Resources, Supervision, Writing – original draft

Affiliation Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain
⨯
Vicente Rubio,

Roles Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain
⨯
Alberto Marina,

Roles Funding acquisition, Resources, Supervision, Visualization, Writing – original draft

Affiliations Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain
⨯
The IBV-Covid19-Pipeline,

Affiliation Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain
⨯
Ron Geller,

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

Affiliation I2SysBio, University of Valencia-CSIC, FISABIO Joint Research Unit Infection and Public Health, Valencia, Spain
⨯
Iñaki Comas,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft

Affiliations Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain, Centro para Investigación Biomédica en Red sobre Epidemiología y Salud Pública (CIBERESP), Valencia, Spain
⨯
Carmen Gil,

Roles Conceptualization, Supervision, Writing – original draft

Affiliation Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), Madrid, Spain
⨯
Mireia Coscolla,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation I2SysBio, University of Valencia-CSIC, FISABIO Joint Research Unit Infection and Public Health, Valencia, Spain
⨯
Modesto Orozco,

Roles Conceptualization, Supervision, Writing – original draft

Affiliations Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain, Department of Biochemistry and Biomedicine, University of Barcelona, Barcelona, Spain
⨯
José Luis Llácer,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain, Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain
⨯
[ ... ],
Jose-Maria Carazo

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: carazo@cnb.csic.es

Affiliation Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain
⨯
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The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

Tiziana Ginex,
Clara Marco-Marín,
Miłosz Wieczór,
Carlos P. Mata,
James Krieger,
Paula Ruiz-Rodriguez,
Maria Luisa López-Redondo,
Clara Francés-Gómez,
Roberto Melero,
Carlos Óscar Sánchez-Sorzano

Published: July 11, 2022
https://doi.org/10.1371/journal.ppat.1010631

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