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Open Access
Peer-reviewed
Research Article
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
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Bryan A. Johnson,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Yiyang Zhou,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Kumari G. Lokugamage,
Roles Conceptualization, Formal analysis, Investigation, Methodology
Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Michelle N. Vu,
Roles Formal analysis, Funding acquisition, Investigation, Methodology
Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Nathen Bopp,
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Patricia A. Crocquet-Valdes,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Birte Kalveram,
Roles Investigation, Methodology
Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Craig Schindewolf,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Yang Liu,
Roles Investigation, Methodology
Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Dionna Scharton,
Roles Investigation, Methodology
Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America
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Jessica A. Plante,
Roles Data curation, Investigation, Methodology, Visualization
Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America
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Xuping Xie,
Roles Investigation, Methodology
Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
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Patricia Aguilar,
Roles Funding acquisition, Supervision
Affiliations Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America
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Scott C. Weaver,
Roles Resources, Supervision, Writing – review & editing
Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America
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Pei-Yong Shi,
Roles Funding acquisition, Supervision, Writing – review & editing
Affiliations Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America, World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America, Institute for Drug Discovery, University of Texas Medical Branch, Galveston, Texas, United States of America
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David H. Walker,
Roles Investigation, Methodology, Writing – review & editing
Affiliations Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America
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Andrew L. Routh,
Roles Conceptualization, Data curation, Funding acquisition, Visualization, Writing – review & editing
Affiliations Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America
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Kenneth S. Plante,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America
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Vineet D. Menachery
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft
* E-mail: Vimenach@utmb.edu
Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America, World Reference Center of Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America
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Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
- Bryan A. Johnson,
- Yiyang Zhou,
- Kumari G. Lokugamage,
- Michelle N. Vu,
- Nathen Bopp,
- Patricia A. Crocquet-Valdes,
- Birte Kalveram,
- Craig Schindewolf,
- Yang Liu,
- Dionna Scharton
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- Published: June 21, 2022
- https://doi.org/10.1371/journal.ppat.1010627