Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice

• Liaoxun Lu ,

  Contributed equally to this work with: Liaoxun Lu, Tianhan Li

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft

  * E-mail: luliaoxun@gris.org.cn (LL); zhanglichen@xxmu.edu.cn (LZ); yinming.liang@gris.org.cn (YL)

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0002-5342-2720

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• Tianhan Li ,

  Contributed equally to this work with: Liaoxun Lu, Tianhan Li

  Roles Data curation, Investigation, Methodology, Software, Visualization

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  ⨯
• Xinyu Feng,

  Roles Data curation, Investigation

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  ⨯
• Zhilong Liu,

  Roles Data curation, Methodology, Visualization

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0001-8196-2401

  ⨯
• Yang Liu,

  Roles Methodology

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

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• Tianzhu Chao,

  Roles Data curation, Methodology

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0002-1739-4697

  ⨯
• Yanrong Gu,

  Roles Software

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0003-0648-5638

  ⨯
• Rong Huang,

  Roles Software

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0001-6256-7481

  ⨯
• Fanghui Zhang,

  Roles Visualization

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  ⨯
• Le He,

  Roles Visualization

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0001-5639-377X

  ⨯
• Binhui Zhou,

  Roles Software

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0001-5970-3665

  ⨯
• Eryan Kong,

  Roles Investigation

  Affiliation Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0002-4086-1441

  ⨯
• Zhuangzhuang Liu,

  Roles Visualization

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, China

  ⨯
• Xugang Wang,

  Roles Investigation

  Affiliation School of Public Health, Xinxiang Medical University, Xinxiang, China

  ⨯
• Zhijun Chen,

  Roles Investigation

  Affiliation The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China

  ⨯
• Hui Wang,

  Roles Writing – review & editing

  Affiliation Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  ⨯
• Marie Malissen,

  Roles Writing – review & editing

  Affiliation Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, Marseille, France

  ⨯
• Bernard Malissen,

  Roles Writing – review & editing

  Affiliation Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, Marseille, France

  ⨯
• Lichen Zhang ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Validation, Writing – original draft

  * E-mail: luliaoxun@gris.org.cn (LL); zhanglichen@xxmu.edu.cn (LZ); yinming.liang@gris.org.cn (YL)

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0002-7810-9941

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•  [ ... ],
• Yinming Liang

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: luliaoxun@gris.org.cn (LL); zhanglichen@xxmu.edu.cn (LZ); yinming.liang@gris.org.cn (YL)

  Affiliations Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China, Henan Key Laboratory of Immunology and Targeted Therapy, Xinxiang Medical University, Xinxiang, China, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, China

  https://orcid.org/0000-0001-9174-4037

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