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Open Access
Peer-reviewed
Research Article
The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus
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Joseph C. Ward ,
Contributed equally to this work with: Joseph C. Ward, Lidia Lasecka-Dykes
Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
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Lidia Lasecka-Dykes ,
Contributed equally to this work with: Joseph C. Ward, Lidia Lasecka-Dykes
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliation Pirbright Institute, Ash Road, Pirbright, Surrey, United Kingdom
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Chris Neil,
Roles Investigation, Writing – review & editing
Affiliation Pirbright Institute, Ash Road, Pirbright, Surrey, United Kingdom
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Oluwapelumi O. Adeyemi,
Roles Investigation, Writing – review & editing
Current address: Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
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Sarah Gold,
Roles Investigation, Writing – review & editing
Affiliation Pirbright Institute, Ash Road, Pirbright, Surrey, United Kingdom
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Niall McLean-Pell,
Roles Investigation
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
⨯ - Caroline Wright,
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Morgan R. Herod,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
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David Kealy,
Roles Investigation
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
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Emma Warner,
Roles Investigation
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
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Terry Jackson,
Roles Validation, Writing – review & editing
Affiliation Pirbright Institute, Ash Road, Pirbright, Surrey, United Kingdom
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Donald P. King,
Roles Funding acquisition
Affiliation Pirbright Institute, Ash Road, Pirbright, Surrey, United Kingdom
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Tobias J. Tuthill,
Roles Funding acquisition, Supervision, Writing – review & editing
Affiliation Pirbright Institute, Ash Road, Pirbright, Surrey, United Kingdom
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David J. Rowlands ,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: d.j.rowlands@leeds.ac.uk (DJR); N.J.Stonehouse@leeds.ac.uk (NJS)
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
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Nicola J. Stonehouse
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: d.j.rowlands@leeds.ac.uk (DJR); N.J.Stonehouse@leeds.ac.uk (NJS)
Affiliation School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
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The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus
- Joseph C. Ward,
- Lidia Lasecka-Dykes,
- Chris Neil,
- Oluwapelumi O. Adeyemi,
- Sarah Gold,
- Niall McLean-Pell,
- Caroline Wright,
- Morgan R. Herod,
- David Kealy,
- Emma Warner
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- Published: June 6, 2022
- https://doi.org/10.1371/journal.ppat.1010589