Haemagglutinin substitutions N125D, D127E, D222G and R223Q improve replicative fitness and vaccine effectiveness of an A/H1N1pdm09 live attenuated influenza vaccine virus by enhancing α-2,6 receptor binding

• Rachael Dempsey ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rachael.dempsey@astrazeneca.com

  Affiliation Flu-BPD, Biopharmaceuticals R&D, AstraZeneca, Liverpool, United Kingdom

  https://orcid.org/0000-0003-3576-701X

  ⨯
• Giulia Tamburrino,

  Roles Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation In vivo expressed biologics, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom

  ⨯
• Katarzyna E. Schewe,

  Roles Investigation, Visualization

  Affiliation Flu-BPD, Biopharmaceuticals R&D, AstraZeneca, Liverpool, United Kingdom

  ⨯
• Jonathan Crowe,

  Roles Formal analysis, Visualization

  Affiliation Flu-BPD, Biopharmaceuticals R&D, AstraZeneca, Liverpool, United Kingdom

  ⨯
• Annalisa Nuccitelli,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation In vivo expressed biologics, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom

  ⨯
• Oliver Dibben

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Flu-BPD, Biopharmaceuticals R&D, AstraZeneca, Liverpool, United Kingdom

  ⨯