A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

• Christian Heuss ,

  Contributed equally to this work with: Christian Heuss, Paul Rothhaar

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Section virus-host interactions, Heidelberg University, Heidelberg, Germany

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• Paul Rothhaar ,

  Contributed equally to this work with: Christian Heuss, Paul Rothhaar

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Section virus-host interactions, Heidelberg University, Heidelberg, Germany

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• Rani Burm,

  Roles Investigation, Writing – review & editing

  Affiliation Laboratory of Liver Infectious Diseases, Ghent University, Gent, Belgium

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• Ji-Young Lee,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany

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• Philipp Ralfs,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Section virus-host interactions, Heidelberg University, Heidelberg, Germany

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• Uta Haselmann,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany

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• Luisa J. Ströh,

  Roles Visualization, Writing – review & editing

  Affiliation Institute of Virology, Hannover Medical School, Hannover, Germany

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• Ombretta Colasanti,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Section virus-host interactions, Heidelberg University, Heidelberg, Germany

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• Cong Si Tran,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Section virus-host interactions, Heidelberg University, Heidelberg, Germany

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• Noemi Schäfer,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infectious Diseases, Molecular Virology, Section virus-host interactions, Heidelberg University, Heidelberg, Germany

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• Paul Schnitzler,

  Roles Resources, Writing – review & editing

  Affiliation Department of Infectious Diseases Virology, University Hospital Heidelberg, Heidelberg, Germany

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• Uta Merle,

  Roles Resources, Writing – review & editing

  Affiliation Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany

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• Ralf Bartenschlager,

  Roles Resources, Writing – review & editing

  Affiliations Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany, German Center for Infection Research, partner site Heidelberg, Heidelberg, Germany, Division Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Arvind H. Patel,

  Roles Resources, Writing – review & editing

  Affiliation MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

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• Frederik Graw,

  Roles Methodology, Software, Writing – review & editing

  Affiliations BioQuant – Center for Quantitative Biology, Heidelberg University, Heidelberg, Germany, Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany

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• Thomas Krey,

  Roles Resources, Writing – review & editing

  Affiliations Institute of Virology, Hannover Medical School, Hannover, Germany, Center of Structural and Cell Biology in Medicine, Institute of Biochemistry, University of Lübeck, Lübeck, Germany, Centre for Structural Systems Biology (CSSB), Hamburg, Germany, German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany, Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany

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• Vibor Laketa,

  Roles Methodology, Software, Writing – review & editing

  Affiliations Department of Infectious Diseases Virology, University Hospital Heidelberg, Heidelberg, Germany, German Center for Infection Research, partner site Heidelberg, Heidelberg, Germany

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• Philip Meuleman,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Laboratory of Liver Infectious Diseases, Ghent University, Gent, Belgium

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•  [ ... ],
• Volker Lohmann

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Volker.Lohmann@med.uni-heidelberg.de

  Affiliations Department of Infectious Diseases, Molecular Virology, Section virus-host interactions, Heidelberg University, Heidelberg, Germany, German Center for Infection Research, partner site Heidelberg, Heidelberg, Germany

  https://orcid.org/0000-0001-8719-7608

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