Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection

• Amanda J. Lee ,

  Contributed equally to this work with: Amanda J. Lee, Emily Feng

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  ¶‡ AJL and EF are co-first authorship on this work. AAA is Lead contact on this work.

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Emily Feng ,

  Contributed equally to this work with: Amanda J. Lee, Emily Feng

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  ¶‡ AJL and EF are co-first authorship on this work. AAA is Lead contact on this work.

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0002-1109-4749

  ⨯
• Marianne V. Chew,

  Roles Formal analysis

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0002-5960-5034

  ⨯
• Elizabeth Balint,

  Roles Investigation

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0001-6310-7807

  ⨯
• Sophie M. Poznanski,

  Roles Investigation

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Elizabeth Giles,

  Roles Investigation

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0002-1104-3319

  ⨯
• Ali Zhang,

  Roles Investigation

  Affiliations Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Art Marzok,

  Roles Investigation

  Affiliations Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0002-7112-6853

  ⨯
• Spencer D. Revill,

  Roles Investigation

  Affiliations Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada, Department of Medicine, Firestone Institute of Respiratory Health, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0003-2165-5228

  ⨯
• Fatemeh Vahedi,

  Roles Investigation

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0001-7377-2835

  ⨯
• Anisha Dubey,

  Roles Investigation

  Affiliations Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada, Department of Medicine, Firestone Institute of Respiratory Health, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Ehab Ayaub,

  Roles Investigation

  Affiliations Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada, Department of Medicine, Firestone Institute of Respiratory Health, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Rodrigo Jimenez-Saiz,

  Roles Investigation

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0002-0606-3251

  ⨯
• Joshua J. C. McGrath,

  Roles Investigation

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Tyrah M. Ritchie,

  Roles Investigation

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Manel Jordana,

  Roles Resources, Supervision

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Danny D. Jonigk,

  Roles Formal analysis, Investigation, Resources

  Affiliation Institute of Pathology, Hannover Medical School, Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany

  https://orcid.org/0000-0002-5251-2281

  ⨯
• Maximilian Ackermann,

  Roles Formal analysis, Investigation, Resources

  Affiliations Institute of Pathology and Molecular Pathology, Helios University Clinic Wuppertal, University of Witten/Herdecke, Wuppertal, Germany, Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

  https://orcid.org/0000-0001-9996-2477

  ⨯
• Kjetil Ask,

  Roles Resources

  Affiliations Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada, Department of Medicine, Firestone Institute of Respiratory Health, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Matthew Miller,

  Roles Resources, Writing – review & editing

  Affiliations Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

  ⨯
• Carl D. Richards,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  ⨯
•  [ ... ],
• Ali A. Ashkar

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: ashkara@mcmaster.ca

  ¶‡ AJL and EF are co-first authorship on this work. AAA is Lead contact on this work.

  Affiliation Department of Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada

  https://orcid.org/0000-0003-1139-1468

  ⨯
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