Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

• Cathrine Scheepers,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Prudence Kgagudi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Nonkululeko Mzindle,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Elin S. Gray,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Current address: School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia

  Affiliation Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa

  ⨯
• Thandeka Moyo-Gwete,

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Bronwen E. Lambson,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Brent Oosthuysen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Batsirai Mabvakure,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Current address: Michigan Department of Health and Human Services, Bureau of Laboratories, Division of Infectious Diseases, Bioinformatics and Sequencing Section, Lansing, Michigan, United States of America

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Nigel J. Garrett,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Centre for the AIDS Programme of Research in South Africa (CAPRISA), KwaZulu-Natal, South Africa

  ⨯
• Salim S. Abdool Karim,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliations Centre for the AIDS Programme of Research in South Africa (CAPRISA), KwaZulu-Natal, South Africa, Department of Epidemiology, Columbia University, New York City, New York, United States of America

  ⨯
• Lynn Morris ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Lynn.Morris@wits.ac.za (LM); pennym@nicd.ac.za (PLM)

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for the AIDS Programme of Research in South Africa (CAPRISA), KwaZulu-Natal, South Africa

  ⨯
• Penny L. Moore

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Lynn.Morris@wits.ac.za (LM); pennym@nicd.ac.za (PLM)

  Affiliations Centre for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa, SA MRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa, Centre for the AIDS Programme of Research in South Africa (CAPRISA), KwaZulu-Natal, South Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

  https://orcid.org/0000-0001-8719-4028

  ⨯