PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

Guangwen Wang; Yuhui Zhao; Yuan Zhou; Li Jiang; Libin Liang; Fandi Kong; Ya Yan; Xuyuan Wang; Yihan Wang; Xia Wen; Xianying Zeng; Guobin Tian; Guohua Deng; Jianzhong Shi; Liling Liu; Hualan Chen; Chengjun Li

doi:10.1371/journal.ppat.1010446

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Open Access

Peer-reviewed

Research Article

PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

Guangwen Wang ,

Contributed equally to this work with: Guangwen Wang, Yuhui Zhao, Yuan Zhou

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Yuhui Zhao ,

Contributed equally to this work with: Guangwen Wang, Yuhui Zhao, Yuan Zhou

Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Yuan Zhou ,

Contributed equally to this work with: Guangwen Wang, Yuhui Zhao, Yuan Zhou

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Li Jiang,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Libin Liang,

Roles Formal analysis, Investigation, Validation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Fandi Kong,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Ya Yan,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Xuyuan Wang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Yihan Wang,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Xia Wen,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Xianying Zeng,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Guobin Tian,

Roles Funding acquisition

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Guohua Deng,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Jianzhong Shi,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Liling Liu,

Roles Investigation

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
Hualan Chen ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: chenhualan@caas.cn (HC); lichengjun@caas.cn (CL)

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China
⨯
[ ... ],
Chengjun Li

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: chenhualan@caas.cn (HC); lichengjun@caas.cn (CL)

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, The People’s Republic of China

https://orcid.org/0000-0001-8460-8619

⨯
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PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence

Guangwen Wang,
Yuhui Zhao,
Yuan Zhou,
Li Jiang,
Libin Liang,
Fandi Kong,
Ya Yan,
Xuyuan Wang,
Yihan Wang,
Xia Wen

Published: April 4, 2022
https://doi.org/10.1371/journal.ppat.1010446

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SUMOylation
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Influenza A virus
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