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Open Access
Peer-reviewed
Research Article
Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection
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Patricia Bartsch,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Christoph Kilian,
Roles Data curation, Formal analysis, Methodology, Software, Visualization
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Malte Hellmig,
Roles Formal analysis, Investigation
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Hans-Joachim Paust,
Roles Formal analysis
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Alina Borchers,
Roles Formal analysis, Methodology
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Amirrtavarshni Sivayoganathan,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Leon Enk,
Roles Investigation
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Yu Zhao,
Roles Formal analysis
Affiliation Institute of Medical Systems Biology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Nikhat Shaikh,
Roles Investigation
Affiliations Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Henning Büttner,
Roles Formal analysis
Affiliation Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Milagros N. Wong,
Roles Investigation
Affiliation III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Victor G. Puelles,
Roles Visualization
Affiliation III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Thorsten Wiech,
Roles Formal analysis, Investigation, Methodology, Visualization
Affiliation Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Richard Flavell,
Roles Resources
Affiliation Department of Immunobiology, Yale University, New Haven, Connecticut, United States of America
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Tobias B. Huber,
Roles Resources
Affiliations Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Jan-Eric Turner,
Roles Conceptualization
Affiliations Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Stefan Bonn,
Roles Formal analysis, Resources, Software, Supervision
Affiliations Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Institute of Medical Systems Biology, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Samuel Huber,
Roles Conceptualization, Funding acquisition
Affiliations Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Nicola Gagliani,
Roles Conceptualization
Affiliations Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Hans-Willi Mittrücker,
Roles Conceptualization
Affiliations Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Holger Rohde,
Roles Conceptualization, Methodology, Resources
Affiliation Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Ulf Panzer,
Roles Conceptualization, Resources
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Christian F. Krebs
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: c.krebs@uke.de
Affiliations III. Department of Medicine, Division of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection
- Patricia Bartsch,
- Christoph Kilian,
- Malte Hellmig,
- Hans-Joachim Paust,
- Alina Borchers,
- Amirrtavarshni Sivayoganathan,
- Leon Enk,
- Yu Zhao,
- Nikhat Shaikh,
- Henning Büttner
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- Published: April 21, 2022
- https://doi.org/10.1371/journal.ppat.1010430