Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primates

• Jacqueline Corry ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: corry.18@osu.edu (JC); smbb@pitt.edu (SMBB)

  Current address: Department of Microbiology, Ohio State University, Columbus, Ohio, United States of America

  Affiliation Department of Infectious Diseases & Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-1942-1529

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• Gwenddolen Kettenburg,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Infectious Diseases & Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-3353-4159

  ⨯
• Amit A. Upadhyay,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Yerkes NHP Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-0952-4164

  ⨯
• Megan Wallace,

  Roles Investigation, Methodology

  Affiliation Department of Infectious Diseases & Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Michelle M. Marti,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Infectious Diseases & Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Elizabeth R. Wonderlich,

  Roles Investigation, Methodology

  Affiliation Department of Infectious Diseases & Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-0773-6569

  ⨯
• Stephanie J. Bissel,

  Roles Formal analysis, Investigation, Methodology

  Current address: Stark Neurosciences Research Institute, Indiana University, Indianapolis, Indiana, United States of America

  Affiliation Division of Neuropathology, Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Kyndal Goss,

  Roles Investigation

  Affiliation Yerkes NHP Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-0863-9998

  ⨯
• Timothy J. Sturgeon,

  Roles Investigation

  Affiliation Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Simon C. Watkins,

  Roles Methodology, Resources, Supervision

  Affiliation Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-4092-1552

  ⨯
• Douglas S. Reed,

  Roles Investigation, Methodology, Supervision

  Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-0076-9023

  ⨯
• Steven E. Bosinger,

  Roles Data curation, Formal analysis, Methodology, Supervision

  Affiliation Yerkes NHP Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Simon M. Barratt-Boyes

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: corry.18@osu.edu (JC); smbb@pitt.edu (SMBB)

  Affiliations Department of Infectious Diseases & Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-8869-4945

  ⨯