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Open Access
Peer-reviewed
Research Article
Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production
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Jin Zhao,
Roles Data curation, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Jiaoshan Chen,
Roles Data curation, Investigation, Methodology, Software, Validation, Visualization
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Congcong Wang,
Roles Investigation, Methodology, Software, Validation
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Yajie Liu,
Roles Investigation, Methodology, Software, Validation
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Minchao Li,
Roles Investigation, Software
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Yanjun Li,
Roles Methodology
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Ruiting Li,
Roles Methodology
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Zirong Han,
Roles Writing – original draft, Writing – review & editing
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Junjian Wang,
Roles Resources
Affiliation Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
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Ling Chen,
Roles Resources
Affiliation State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China
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Yuelong Shu,
Roles Resources
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Genhong Cheng ,
Roles Resources, Writing – original draft, Writing – review & editing
* E-mail: gcheng@mednet.ucla.edu (GC); suncaijun@mail.sysu.edu.cn (CS)
Affiliation Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States of America
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Caijun Sun
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: gcheng@mednet.ucla.edu (GC); suncaijun@mail.sysu.edu.cn (CS)
Affiliations School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China, Key Laboratory of Tropical Disease Control (Sun Yat-sen university), Ministry of Education, Guangzhou, China
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Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production
- Jin Zhao,
- Jiaoshan Chen,
- Congcong Wang,
- Yajie Liu,
- Minchao Li,
- Yanjun Li,
- Ruiting Li,
- Zirong Han,
- Junjian Wang,
- Ling Chen
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- Published: March 2, 2022
- https://doi.org/10.1371/journal.ppat.1010366