Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

• Yogavel Manickam ,

  Contributed equally to this work with: Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar

  Roles Funding acquisition, Methodology, Supervision, Visualization

  Affiliation Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

  ⨯
• Nipun Malhotra ,

  Contributed equally to this work with: Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, United States of America

  Affiliation Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

  https://orcid.org/0000-0002-2748-6747

  ⨯
• Siddhartha Mishra ,

  Contributed equally to this work with: Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India, ICMR-National Institute of Malaria Research (NIMR), New Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

  https://orcid.org/0000-0003-0907-9256

  ⨯
• Palak Babbar ,

  Contributed equally to this work with: Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar

  Roles Investigation, Supervision

  Affiliation Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

  ⨯
• Abhishek Dusane,

  Roles Investigation, Methodology

  Affiliation Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India

  https://orcid.org/0000-0002-3871-0281

  ⨯
• Benoît Laleu,

  Roles Funding acquisition, Project administration

  Affiliation Medicines for Malaria Venture (MMV), International Center Cointrin (ICC), Geneva, Switzerland

  ⨯
• Valeria Bellini,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France

  https://orcid.org/0000-0003-2066-9206

  ⨯
• Mohamed-Ali Hakimi,

  Roles Funding acquisition, Supervision

  Affiliation Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France

  ⨯
• Alexandre Bougdour ,

  Roles Formal analysis, Investigation, Supervision, Visualization, Writing – review & editing

  * E-mail: alexandre.bougdour@univ-grenoble-alpes.fr (AB); directornimr@gmail.com (AS)

  Affiliation Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France

  ⨯
• Amit Sharma

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: alexandre.bougdour@univ-grenoble-alpes.fr (AB); directornimr@gmail.com (AS)

  Affiliations Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India, ICMR-National Institute of Malaria Research (NIMR), New Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

  https://orcid.org/0000-0002-3305-0034

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