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Open Access
Peer-reviewed
Research Article
The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist
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Christian Berg,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Unit for Infectious Diseases, Department of Medicine, Herlev-Gentofte Hospital, University of Copenhagen, Herlev, Denmark
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Michael J. Wedemeyer,
Roles Formal analysis, Investigation, Visualization, Writing – original draft
Affiliation Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
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Motiejus Melynis,
Roles Investigation
Affiliation Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
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Roman R. Schlimgen,
Roles Investigation, Methodology, Visualization, Writing – original draft
Affiliation Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
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Lasse H. Hansen,
Roles Investigation
Affiliations Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen N, Denmark
⨯ - Jon Våbenø,
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Francis C. Peterson,
Roles Investigation, Methodology, Supervision
Affiliation Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
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Brian F. Volkman,
Roles Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing
Affiliation Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
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Mette M. Rosenkilde ,
Roles Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing
* E-mail: rosenkilde@sund.ku.dk (MMR); Hans.Rudolf.von.Luttichau@regionh.dk (HRL)
Affiliation Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
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Hans R. Lüttichau
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: rosenkilde@sund.ku.dk (MMR); Hans.Rudolf.von.Luttichau@regionh.dk (HRL)
Affiliations Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Unit for Infectious Diseases, Department of Medicine, Herlev-Gentofte Hospital, University of Copenhagen, Herlev, Denmark
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The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist
- Christian Berg,
- Michael J. Wedemeyer,
- Motiejus Melynis,
- Roman R. Schlimgen,
- Lasse H. Hansen,
- Jon Våbenø,
- Francis C. Peterson,
- Brian F. Volkman,
- Mette M. Rosenkilde,
- Hans R. Lüttichau
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- Published: March 10, 2022
- https://doi.org/10.1371/journal.ppat.1010355