Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung

Xinxin Wang; Jie Luo; Zhiyuan Wen; Lei Shuai; Chong Wang; Gongxun Zhong; Xijun He; Huizhen Cao; Renqiang Liu; Jinying Ge; Ronghong Hua; Ziruo Sun; Xijun Wang; Jinliang Wang; Zhigao Bu

doi:10.1371/journal.ppat.1010343

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Open Access

Peer-reviewed

Research Article

Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung

Xinxin Wang,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Jie Luo,

Roles Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Zhiyuan Wen,

Roles Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Lei Shuai,

Roles Funding acquisition, Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Chong Wang,

Roles Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Gongxun Zhong,

Roles Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Xijun He,

Roles Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Huizhen Cao,

Roles Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Renqiang Liu,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Jinying Ge,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Ronghong Hua,

Roles Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Ziruo Sun,

Roles Methodology

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Xijun Wang,

Roles Funding acquisition, Resources

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Jinliang Wang ,

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wangjinliang@caas.cn (JW); buzhigao@caas.cn (ZB)

Affiliation State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China
⨯
Zhigao Bu

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wangjinliang@caas.cn (JW); buzhigao@caas.cn (ZB)

Affiliations State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, P. R. China

https://orcid.org/0000-0001-9242-4211

⨯

Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung

Xinxin Wang,
Jie Luo,
Zhiyuan Wen,
Lei Shuai,
Chong Wang,
Gongxun Zhong,
Xijun He,
Huizhen Cao,
Renqiang Liu,
Jinying Ge

Published: February 17, 2022
https://doi.org/10.1371/journal.ppat.1010343

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