CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A Streptococcus

Nicola Horstmann; Kevin S. Myers; Chau Nguyen Tran; Anthony R. Flores; Samuel A. Shelburne III

doi:10.1371/journal.ppat.1010341

Loading metrics

Open Access

Peer-reviewed

Research Article

CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A Streptococcus

Nicola Horstmann,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Kevin S. Myers,

Roles Funding acquisition, Investigation, Methodology, Software, Writing – review & editing

Affiliation Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Chau Nguyen Tran,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Anthony R. Flores,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Software, Visualization, Writing – review & editing

Affiliations Center for Antimicrobial Resistance and Microbial Genomics McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
⨯
Samuel A. Shelburne III

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sshelburne@mdanderson.org

Affiliations Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

https://orcid.org/0000-0001-9721-263X

⨯

CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A Streptococcus

Nicola Horstmann,
Kevin S. Myers,
Chau Nguyen Tran,
Anthony R. Flores,
Samuel A. Shelburne III

Published: February 18, 2022
https://doi.org/10.1371/journal.ppat.1010341

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.
Sequence motif analysis
Is the Subject Area "Sequence motif analysis" applicable to this article?

Thanks for your feedback.
Virulence factors
Is the Subject Area "Virulence factors" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
DNA
Is the Subject Area "DNA" applicable to this article?

Thanks for your feedback.
Regulator genes
Is the Subject Area "Regulator genes" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Promoter regions
Is the Subject Area "Promoter regions" applicable to this article?

Thanks for your feedback.