Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns

Ilhan Tomris; Kim M. Bouwman; Youri Adolfs; Danny Noack; Roosmarijn van der Woude; Gius Kerster; Sander Herfst; Rogier W. Sanders; Marit J. van Gils; Geert-Jan Boons; Bart L. Haagmans; R. Jeroen Pasterkamp; Barry Rockx; Robert P. de Vries

doi:10.1371/journal.ppat.1010340

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Open Access

Peer-reviewed

Research Article

Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns

Ilhan Tomris,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
⨯
Kim M. Bouwman,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

Affiliation Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0003-1794-6735

⨯
Youri Adolfs,

Roles Data curation, Investigation, Software, Visualization

Affiliation Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands
⨯
Danny Noack,

Roles Investigation, Resources

Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0003-1845-7511

⨯
Roosmarijn van der Woude,

Roles Investigation

Affiliation Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0003-2151-5604

⨯
Gius Kerster,

Roles Resources

Affiliation Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

https://orcid.org/0000-0001-6880-7351

⨯
Sander Herfst,

Roles Resources

Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0001-9866-8903

⨯
Rogier W. Sanders,

Roles Resources

Affiliations Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands, Department of Microbiology and Immunology, Weill Medical College of Cornell University, Ney York City, New York, United States of America
⨯
Marit J. van Gils,

Roles Resources

Affiliation Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

https://orcid.org/0000-0003-3422-8161

⨯
Geert-Jan Boons,

Roles Resources, Supervision, Writing – review & editing

Affiliations Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America, Department of Chemistry, University of Georgia, Athens, Georgia, United States of America
⨯
Bart L. Haagmans,

Roles Resources, Supervision, Writing – review & editing

Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0001-6221-2015

⨯
R. Jeroen Pasterkamp,

Roles Methodology, Resources, Software, Supervision

Affiliation Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands
⨯
Barry Rockx,

Roles Investigation, Resources, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0003-2463-027X

⨯
Robert P. de Vries

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft

* E-mail: r.vries@uu.nl

Affiliation Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0002-1586-4464

⨯

Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns

Ilhan Tomris,
Kim M. Bouwman,
Youri Adolfs,
Danny Noack,
Roosmarijn van der Woude,
Gius Kerster,
Sander Herfst,
Rogier W. Sanders,
Marit J. van Gils,
Geert-Jan Boons

Published: March 7, 2022
https://doi.org/10.1371/journal.ppat.1010340
See the preprint

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