Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

• Paula Ortega-Gonzalez,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, campus UAM, Cantoblanco, Madrid, Spain, PhD Program in Molecular Biosciences, Autonoma de Madrid University, Madrid, Spain, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Institute of Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-2882-3271

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• Gwen Taylor,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Institute of Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-9276-087X

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• Rohit K. Jangra,

  Roles Methodology, Resources, Writing – review & editing

  Current address: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, United State of America

  Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

  https://orcid.org/0000-0002-3119-0869

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• Raquel Tenorio,

  Roles Writing – review & editing

  Affiliation Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, campus UAM, Cantoblanco, Madrid, Spain

  https://orcid.org/0000-0003-0547-155X

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• Isabel Fernandez de Castro,

  Roles Writing – review & editing

  Affiliation Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, campus UAM, Cantoblanco, Madrid, Spain

  https://orcid.org/0000-0002-5388-8934

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• Bernardo A. Mainou,

  Roles Methodology, Writing – review & editing

  Current address: Centers for Disease Control and Prevention, Atlanta, Georgia, United State of America

  Affiliation Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

  https://orcid.org/0000-0002-7721-183X

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• Robert C. Orchard,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  https://orcid.org/0000-0001-8216-4946

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• Craig B. Wilen,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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• Pamela H. Brigleb,

  Roles Writing – review & editing

  Affiliations Institute of Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Jorna Sojati,

  Roles Writing – review & editing

  Affiliations Institute of Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-3908-6126

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• Kartik Chandran,

  Roles Resources, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• Martin Sachse,

  Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, campus UAM, Cantoblanco, Madrid, Spain

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• Cristina Risco ,

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: crisco@cnb.csic.es (C.R); terence.dermody@chp.edu (T.S.D)

  Affiliation Cell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, campus UAM, Cantoblanco, Madrid, Spain

  https://orcid.org/0000-0001-7501-5934

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• Terence S. Dermody

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: crisco@cnb.csic.es (C.R); terence.dermody@chp.edu (T.S.D)

  Affiliations Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Institute of Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-1853-8741

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