p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling

Chao Ma; Yuhan Li; Yanan Zong; Tony Velkov; Chenxi Wang; Xinyu Yang; Ming Zhang; Zhimin Jiang; Haoran Sun; Qi Tong; Honglei Sun; Juan Pu; Munir Iqbal; Jinhua Liu; Chongshan Dai; Yipeng Sun

doi:10.1371/journal.ppat.1010295

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Open Access

Peer-reviewed

Research Article

p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling

Chao Ma,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Yuhan Li,

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Yanan Zong,

Roles Investigation

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Tony Velkov,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, the University of Melbourne, Parkville, Victoria, Australia
⨯
Chenxi Wang,

Roles Data curation, Writing – review & editing

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Xinyu Yang,

Roles Investigation

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Ming Zhang,

Roles Writing – review & editing

Affiliation Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia, United States of America
⨯
Zhimin Jiang,

Roles Methodology

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Haoran Sun,

Roles Methodology

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Qi Tong,

Roles Project administration

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Honglei Sun,

Roles Writing – review & editing

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Juan Pu,

Roles Writing – review & editing

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Munir Iqbal,

Roles Funding acquisition, Project administration, Writing – review & editing

Affiliation The Pirbright Institute, Pirbright, Woking, United Kingdom
⨯
Jinhua Liu ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: ljh@cau.edu.cn (JL); daichongshan@cau.edu.cn (CD); syp@cau.edu.cn (YS)

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
Chongshan Dai ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ljh@cau.edu.cn (JL); daichongshan@cau.edu.cn (CD); syp@cau.edu.cn (YS)

Affiliation Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China
⨯
[ ... ],
Yipeng Sun

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ljh@cau.edu.cn (JL); daichongshan@cau.edu.cn (CD); syp@cau.edu.cn (YS)

Affiliation Key Laboratory of Avian Influenza of the Ministry of Agriculture and Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China

https://orcid.org/0000-0001-9399-0039

⨯
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p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling

Chao Ma,
Yuhan Li,
Yanan Zong,
Tony Velkov,
Chenxi Wang,
Xinyu Yang,
Ming Zhang,
Zhimin Jiang,
Haoran Sun,
Qi Tong

Published: February 18, 2022
https://doi.org/10.1371/journal.ppat.1010295

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