Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity

• Ying Du ,

  Contributed equally to this work with: Ying Du, Nina Hertoghs

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-9604-2368

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• Nina Hertoghs ,

  Contributed equally to this work with: Ying Du, Nina Hertoghs

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Fergal J. Duffy,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-4675-0937

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• Jason Carnes,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Suzanne M. McDermott,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2158-1695

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• Maxwell L. Neal,

  Roles Formal analysis, Software, Validation, Visualization

  Affiliation Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-2390-6572

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• Katharine V. Schwedhelm,

  Roles Methodology, Resources, Supervision, Validation

  Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-9806-8342

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• M. Juliana McElrath,

  Roles Funding acquisition, Resources, Supervision

  Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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• Stephen C. De Rosa,

  Roles Methodology, Resources, Supervision, Validation

  Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-3871-4618

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• John D. Aitchison,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Kenneth D. Stuart

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: ken.stuart@seattlechildrens.org

  Affiliations Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-4064-9758

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