Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

• Jennifer L. Small-Saunders,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

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• Laura M. Hagenah,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Kathryn J. Wicht,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Satish K. Dhingra,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Ioanna Deni,

  Roles Data curation, Formal analysis

  Affiliation Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0002-5266-8243

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• Jonathan Kim,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, New York United States of America

  https://orcid.org/0000-0003-2594-3251

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• Jeremie Vendome,

  Roles Data curation, Investigation, Methodology, Software

  Affiliation Schrödinger, Inc., New York, New York, United States of America

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• Eva Gil-Iturbe,

  Roles Investigation

  Affiliation Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0002-4046-5756

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• Paul D. Roepe,

  Roles Funding acquisition, Methodology, Writing – review & editing

  Affiliations Department of Chemistry, Georgetown University, Washington, DC, United States of America, Department of Biochemistry and Cellular and Molecular Biology, Georgetown University, Washington, DC, United States of America

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• Monica Mehta,

  Roles Writing – original draft

  Affiliation Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

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• Filippo Mancia,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliation Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, New York United States of America

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• Matthias Quick,

  Roles Data curation, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, United States of America, Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, United States of America, Center for Molecular Recognition, Columbia University Irving Medical Center, New York, New York, United States of America

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• Margaret J. Eppstein,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliations Vermont Complex Systems Center, University of Vermont, Burlington, Vermont, United States of America, Department of Computer Science, University of Vermont, Burlington, Vermont, United States of America, Translational Global Infectious Diseases Research Center, University of Vermont, Burlington, Vermont, United States of America

  https://orcid.org/0000-0002-7775-1430

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• David A. Fidock

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: df2260@cumc.columbia.edu

  Affiliations Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0001-6753-8938

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