The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription

• Afam A. Okoye ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: okoyea@ohsu.edu (AAO); nicolas.chomont@umontreal.ca (NC)

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0001-9671-550X

  ⨯
• Rémi Fromentin,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration

  Affiliations Centre de Recherche du CHUM, Montréal, Québec, Canada, Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Québec, Canada

  https://orcid.org/0000-0002-8153-1799

  ⨯
• Hiroshi Takata,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0003-1457-6919

  ⨯
• Jessica H. Brehm,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources

  Affiliation ViiV Healthcare, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0002-4589-279X

  ⨯
• Yoshinori Fukazawa,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0001-6613-5029

  ⨯
• Bryan Randall,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

  ⨯
• Marion Pardons,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Centre de Recherche du CHUM, Montréal, Québec, Canada, Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Québec, Canada

  ⨯
• Vincent Tai,

  Roles Data curation, Resources

  Affiliation ViiV Healthcare, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0003-4623-4438

  ⨯
• Jun Tang,

  Roles Data curation, Resources

  Affiliation ViiV Healthcare, Research Triangle Park, North Carolina, United States of America

  ⨯
• Jeremy Smedley,

  Roles Investigation, Project administration

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0003-3369-4662

  ⨯
• Michael Axthelm,

  Roles Investigation, Project administration

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0002-1984-5906

  ⨯
• Jeffrey D. Lifson,

  Roles Investigation, Resources, Writing – original draft, Writing – review & editing

  Affiliation AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, Maryland, United States of America

  ⨯
• Louis J. Picker,

  Roles Investigation, Resources, Writing – original draft

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America

  ⨯
• David Favre,

  Roles Conceptualization, Resources

  Affiliations UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, HIV Discovery Performance Unit, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

  https://orcid.org/0000-0002-0231-114X

  ⨯
• Lydie Trautmann ,

  Contributed equally to this work with: Lydie Trautmann, Nicolas Chomont

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0002-3012-0009

  ⨯
•  [ ... ],
• Nicolas Chomont

  Contributed equally to this work with: Lydie Trautmann, Nicolas Chomont

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: okoyea@ohsu.edu (AAO); nicolas.chomont@umontreal.ca (NC)

  Affiliations Centre de Recherche du CHUM, Montréal, Québec, Canada, Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Québec, Canada

  https://orcid.org/0000-0001-9747-5018

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