Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection

• Aaqib Sohail ,

  Roles Formal analysis, Investigation, Writing – review & editing

  Current address: Department of Medicine, Harvard Medical School, the Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Boston, Massachusetts

  ¶‡ AS, AI, and NS share first authorship on this work. FC, MT, FW and MW are joint second authors on this work (listed in alphabetical order).

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

  https://orcid.org/0000-0002-5917-7316

  ⨯
• Azeem A. Iqbal ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  ¶‡ AS, AI, and NS share first authorship on this work. FC, MT, FW and MW are joint second authors on this work (listed in alphabetical order).

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

  ⨯
• Nishika Sahini ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  ¶‡ AS, AI, and NS share first authorship on this work. FC, MT, FW and MW are joint second authors on this work (listed in alphabetical order).

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

  https://orcid.org/0000-0001-6951-9781

  ⨯
• Fangfang Chen ,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  ¶‡ AS, AI, and NS share first authorship on this work. FC, MT, FW and MW are joint second authors on this work (listed in alphabetical order).

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

  https://orcid.org/0000-0001-7396-4052

  ⨯
• Mohamed Tantawy ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ AS, AI, and NS share first authorship on this work. FC, MT, FW and MW are joint second authors on this work (listed in alphabetical order).

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany, Hormones Department, Medical Research and Clinical Studies Institute, National Research Center, Dokki, Giza, Egypt, Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Center, Dokki, Giza, Egypt

  ⨯
• Syed F.H. Waqas ,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  ¶‡ AS, AI, and NS share first authorship on this work. FC, MT, FW and MW are joint second authors on this work (listed in alphabetical order).

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

  ⨯
• Moritz Winterhoff ,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

  ¶‡ AS, AI, and NS share first authorship on this work. FC, MT, FW and MW are joint second authors on this work (listed in alphabetical order).

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

  ⨯
• Thomas Ebensen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

  ⨯
• Kristin Schultz,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany

  ⨯
• Robert Geffers,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  Affiliation Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany

  https://orcid.org/0000-0003-4409-016X

  ⨯
• Klaus Schughart,

  Roles Formal analysis, Validation, Visualization

  Affiliations Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany, University of Veterinary Medicine Hannover, Hannover, Germany, Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-6824-7523

  ⨯
• Matthias Preusse,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany

  https://orcid.org/0000-0002-2775-3139

  ⨯
• Mahmoud Shehata,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany, Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt

  ⨯
• Heike Bähre,

  Roles Methodology, Resources

  Affiliation Research Core Unit Metabolomics, Hannover Medical School, Hannover, Germany

  ⨯
• Marina C. Pils,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Mouse Pathology Platform, Helmholtz Centre for Infection Research, Braunschweig, Germany

  ⨯
• Carlos A. Guzman,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

  https://orcid.org/0000-0002-2913-5254

  ⨯
• Ahmed Mostafa,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany, Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt

  ⨯
• Stephan Pleschka,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliations Institute for Medical Virology, Justus-Liebig-University, Giessen, Germany, German Center for Infection Research (DZIF) partner site Giessen, Germany

  https://orcid.org/0000-0002-7372-7089

  ⨯
• Christine Falk,

  Roles Formal analysis, Resources

  Affiliation Department of Transplantation Immunology, Hannover Medical School, Hannover, Germany

  https://orcid.org/0000-0003-1376-7318

  ⨯
• Alessandro Michelucci,

  Roles Conceptualization, Resources

  Affiliations Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg

  https://orcid.org/0000-0003-1230-061X

  ⨯
•  [ ... ],
• Frank Pessler

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: frank.pessler@helmholtz-hzi.de, frank.pesslerwincore.de

  Affiliations Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany, Centre for Individualised Infection Medicine, Hannover, Germany

  https://orcid.org/0000-0002-3434-2311

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