Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy

Jiacheng Lin; Limin Yin; Xia-Zhen Xu; He-Chen Sun; Zhi-Hua Huang; Xue-Yun Ni; Yan Chen; Xu Lin

doi:10.1371/journal.ppat.1010204

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Open Access

Peer-reviewed

Research Article

Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy

Jiacheng Lin,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China, Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China
⨯
Limin Yin,

Roles Formal analysis, Investigation, Validation

Affiliation Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China
⨯
Xia-Zhen Xu,

Roles Formal analysis, Investigation, Validation

Affiliation Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China
⨯
He-Chen Sun,

Roles Formal analysis, Investigation, Validation

Affiliation Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China
⨯
Zhi-Hua Huang,

Roles Formal analysis, Investigation

Affiliation Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China
⨯
Xue-Yun Ni,

Roles Formal analysis, Investigation, Validation

Affiliation Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China
⨯
Yan Chen,

Roles Investigation, Validation

Affiliations Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China, Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China
⨯
Xu Lin

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: linxu@mail.fjmu.edu.cn

Affiliations Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China, Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China
⨯

Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy

Jiacheng Lin,
Limin Yin,
Xia-Zhen Xu,
He-Chen Sun,
Zhi-Hua Huang,
Xue-Yun Ni,
Yan Chen,
Xu Lin

Published: January 14, 2022
https://doi.org/10.1371/journal.ppat.1010204

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Polymers
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Lysosomes
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Transfection
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Hepatitis B virus
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Capsids
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Immunoprecipitation
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