Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

• Catarina E. Hioe ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: catarina.hioe@mssm.edu, catarina.hioe@va.gov

  Affiliations Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, James J. Peters VA Medical Center, Bronx, New York, New York, United States of America

  https://orcid.org/0000-0002-9245-9788

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• Guangming Li,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

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• Xiaomei Liu,

  Roles Investigation, Resources

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Ourania Tsahouridis,

  Roles Formal analysis, Investigation

  Affiliation Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America

  https://orcid.org/0000-0003-0621-6753

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• Xiuting He,

  Roles Formal analysis, Investigation

  Affiliation Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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• Masaya Funaki,

  Roles Formal analysis, Investigation

  Affiliation Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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• Jéromine Klingler,

  Roles Formal analysis, Investigation

  Affiliations Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, James J. Peters VA Medical Center, Bronx, New York, New York, United States of America

  https://orcid.org/0000-0002-2313-9932

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• Alex F. Tang,

  Roles Formal analysis, Investigation

  Affiliations Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, School of Medicine, University of California, San Francisco, California, United States of America

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• Roya Feyznezhad,

  Roles Formal analysis, Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  https://orcid.org/0000-0002-0895-6782

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• Daniel W. Heindel,

  Roles Formal analysis, Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Xiao-Hong Wang,

  Roles Formal analysis, Investigation

  Affiliation VA New York Harbor Healthcare System–Manhattan, New York, New York, United States of America

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• David A. Spencer,

  Roles Formal analysis, Investigation

  Affiliation Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

  https://orcid.org/0000-0002-5789-6202

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• Guangnan Hu,

  Roles Formal analysis, Investigation

  Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

  https://orcid.org/0000-0003-1570-6770

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• Namita Satija,

  Roles Formal analysis, Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Jérémie Prévost,

  Roles Formal analysis, Investigation

  Affiliations Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada, Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada

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• Andrés Finzi,

  Roles Formal analysis, Funding acquisition, Methodology, Resources

  Affiliations Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada, Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada

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• Ann J. Hessell,

  Roles Formal analysis, Funding acquisition, Methodology, Resources

  Affiliation Division of Pathobiology & Immunology, Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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• Shixia Wang,

  Roles Formal analysis, Funding acquisition, Methodology, Resources

  Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

  https://orcid.org/0000-0002-7748-8468

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• Shan Lu,

  Roles Formal analysis, Funding acquisition, Methodology, Resources

  Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Benjamin K. Chen,

  Roles Formal analysis, Funding acquisition, Methodology, Resources

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  https://orcid.org/0000-0002-5404-1997

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• Susan Zolla-Pazner,

  Roles Formal analysis, Funding acquisition, Methodology, Resources

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Chitra Upadhyay,

  Roles Formal analysis, Funding acquisition, Methodology, Resources

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  https://orcid.org/0000-0002-4524-1532

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• Raymond Alvarez,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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•  [ ... ],
• Lishan Su

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis, and Cancer, Institute of Human Virology, Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Laboratory of Viral Pathogenesis and Immunotherapy, Division of Virology, Pathogenesis and Cancer, Institute of Human Virology, Departments of Pharmacology and Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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