SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection

Abigael Eva Chaouat; Hagit Achdout; Inbal Kol; Orit Berhani; Gil Roi; Einat B. Vitner; Sharon Melamed; Boaz Politi; Eran Zahavy; Ilija Brizic; Tihana Lenac Rovis; Or Alfi; Dana Wolf; Stipan Jonjic; Tomer Israely; Ofer Mandelboim

doi:10.1371/journal.ppat.1010175

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Open Access

Peer-reviewed

Research Article

SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection

Abigael Eva Chaouat ,

Contributed equally to this work with: Abigael Eva Chaouat, Hagit Achdout

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯
Hagit Achdout ,

Contributed equally to this work with: Abigael Eva Chaouat, Hagit Achdout

Roles Investigation, Methodology, Resources

Affiliation Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel
⨯
Inbal Kol,

Roles Investigation, Methodology

Affiliation The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯
Orit Berhani,

Roles Visualization, Writing – review & editing

Affiliation The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel
⨯
Gil Roi,

Roles Investigation

Affiliation The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel

https://orcid.org/0000-0002-9778-4993

⨯
Einat B. Vitner,

Roles Investigation, Resources

Affiliation Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel
⨯
Sharon Melamed,

Roles Investigation, Resources

Affiliation Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel

https://orcid.org/0000-0001-9234-0501

⨯
Boaz Politi,

Roles Investigation, Resources

Affiliation Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel
⨯
Eran Zahavy,

Roles Investigation, Resources

Affiliation Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel

https://orcid.org/0000-0002-5531-9786

⨯
Ilija Brizic,

Roles Funding acquisition, Investigation

Affiliation Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

https://orcid.org/0000-0001-8839-7839

⨯
Tihana Lenac Rovis,

Roles Investigation

Affiliation Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

https://orcid.org/0000-0002-3299-1334

⨯
Or Alfi,

Roles Investigation, Resources

Affiliations Lautenberg Center for General and Tumor Immunology, The Hebrew University Faculty of Medicine, Jerusalem, Israel, Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
⨯
Dana Wolf,

Roles Methodology, Resources

Affiliations Lautenberg Center for General and Tumor Immunology, The Hebrew University Faculty of Medicine, Jerusalem, Israel, Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel

https://orcid.org/0000-0001-5507-4160

⨯
Stipan Jonjic,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
⨯
Tomer Israely,

Roles Investigation, Resources

Affiliation Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel
⨯
[ ... ],
Ofer Mandelboim

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: oferm@ekmd.huji.ac.il.

Affiliation The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel Canada (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel

https://orcid.org/0000-0002-9354-1855

⨯
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SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection

Abigael Eva Chaouat,
Hagit Achdout,
Inbal Kol,
Orit Berhani,
Gil Roi,
Einat B. Vitner,
Sharon Melamed,
Boaz Politi,
Eran Zahavy,
Ilija Brizic

Published: December 20, 2021
https://doi.org/10.1371/journal.ppat.1010175

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