Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication

• Limeng Sun ,

  Contributed equally to this work with: Limeng Sun, Changzhi Zhao

  Roles Conceptualization, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, P. R. China

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• Changzhi Zhao ,

  Contributed equally to this work with: Limeng Sun, Changzhi Zhao

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, P. R. China

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• Zhen Fu,

  Roles Formal analysis, Validation

  Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, P. R. China

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• Yanan Fu,

  Roles Formal analysis, Validation

  Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, P. R. China

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• Zhelin Su,

  Roles Formal analysis, Validation

  Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, P. R. China

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• Yangyang Li,

  Roles Methodology

  Affiliation Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, P. R. China

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• Yuan Zhou,

  Roles Formal analysis, Validation

  Affiliation Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, P. R. China

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• Yubei Tan,

  Roles Formal analysis, Validation

  Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, P. R. China

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• Jingjin Li,

  Roles Data curation, Formal analysis

  Affiliation Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, P. R. China

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• Yixin Xiang,

  Roles Formal analysis, Validation

  Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, P. R. China

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• Xiongwei Nie,

  Roles Data curation, Software, Visualization

  Affiliation Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, P. R. China

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• Jinfu Zhang,

  Roles Validation

  Affiliation Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, P. R. China

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• Fei Liu,

  Roles Methodology

  Affiliation Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, P. R. China

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• Shuhong Zhao,

  Roles Conceptualization

  Affiliations Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, P. R. China, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, Wuhan, P. R. China

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• Shengsong Xie ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: ssxie@mail.hzau.edu.cn (SX); penggq@mail.hzau.edu.cn (GP)

  Affiliation Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, P. R. China

  https://orcid.org/0000-0002-8301-877X

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•  [ ... ],
• Guiqing Peng

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  * E-mail: ssxie@mail.hzau.edu.cn (SX); penggq@mail.hzau.edu.cn (GP)

  Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, P. R. China

  https://orcid.org/0000-0001-8813-6663

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