An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults

• Vinicius A. Vieira,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Paediatrics, University of Oxford, Oxford, United Kingdom, HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

  https://orcid.org/0000-0002-4901-0424

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• Emily Adland,

  Roles Data curation

  Affiliation Department of Paediatrics, University of Oxford, Oxford, United Kingdom

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• David F. G. Malone,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliation Department of Paediatrics, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0001-9144-1941

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• Maureen P. Martin,

  Roles Formal analysis, Methodology

  Affiliation Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America

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• Andreas Groll,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Statistics, TU Dortmund University, Dortmund, Germany

  https://orcid.org/0000-0001-6787-9118

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• M. Azim Ansari,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Maria C. Garcia-Guerrero,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation IrsiCaixa AIDS Research Institute, Badalona, Spain

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• Mari C. Puertas,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations IrsiCaixa AIDS Research Institute, Badalona, Spain, CIBER en Enfermedades Infecciosas, Madrid, Spain

  https://orcid.org/0000-0002-6750-2318

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• Maximilian Muenchhoff,

  Roles Data curation, Writing – review & editing

  Affiliations Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Munich, Germany

  https://orcid.org/0000-0001-7016-0470

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• Claudia Fortuny Guash,

  Roles Data curation

  Affiliations Infectious Diseases and Systemic Inflammatory Response in Pediatrics, Infectious Diseases Unit, Department of Pediatrics, Sant Joan de Déu Hospital Research Foundation, Barcelona, Spain, Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain, Department of Pediatrics, University of Barcelona, Barcelona, Spain, Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain

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• Christian Brander,

  Roles Data curation, Writing – review & editing

  Affiliations IrsiCaixa AIDS Research Institute, Badalona, Spain, CIBER en Enfermedades Infecciosas, Madrid, Spain, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

  ⨯
• Javier Martinez-Picado,

  Roles Methodology, Writing – review & editing

  Affiliations IrsiCaixa AIDS Research Institute, Badalona, Spain, CIBER en Enfermedades Infecciosas, Madrid, Spain, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

  https://orcid.org/0000-0002-4916-2129

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• Alasdair Bamford,

  Roles Data curation, Writing – review & editing

  Affiliations Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

  https://orcid.org/0000-0003-4764-229X

  ⨯
• Gareth Tudor-Williams,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Infectious Diseases, Imperial College, London, United Kingdom

  https://orcid.org/0000-0002-4488-849X

  ⨯
• Thumbi Ndung’u,

  Roles Data curation, Writing – review & editing

  Affiliations HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Africa Health Research Institute (AHRI), Durban, South Africa, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America, Max Planck Institute for Infection Biology, Chariteplatz, Berlin, Germany, Division of Infection and Immunity, University College London, London, United Kingdom

  ⨯
• Bruce D. Walker,

  Roles Data curation, Writing – review & editing

  Affiliations HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Africa Health Research Institute (AHRI), Durban, South Africa, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America

  ⨯
• Veron Ramsuran,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa, Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa

  https://orcid.org/0000-0003-1590-9893

  ⨯
• John Frater,

  Roles Investigation, Writing – review & editing

  Affiliations Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom

  ⨯
• Pieter Jooste,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Paediatrics, Kimberley Hospital, Kimberley, South Africa

  https://orcid.org/0000-0002-8635-2255

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• Dimitra Peppa,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Division of Infection and Immunity, University College London, London, United Kingdom

  ⨯
• Mary Carrington,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliations Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America

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•  [ ... ],
• Philip J. R. Goulder

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: philip.goulder@paediatrics.ox.ac.uk

  Affiliations Department of Paediatrics, University of Oxford, Oxford, United Kingdom, HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

  https://orcid.org/0000-0002-9842-4674

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