Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

Wenlin Ren; Jun Lan; Xiaohui Ju; Mingli Gong; Quanxin Long; Zihui Zhu; Yanying Yu; Jianping Wu; Jin Zhong; Rong Zhang; Shilong Fan; Guocai Zhong; Ailong Huang; Xinquan Wang; Qiang Ding

doi:10.1371/journal.ppat.1010053

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Open Access

Peer-reviewed

Research Article

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

Wenlin Ren ,

Contributed equally to this work with: Wenlin Ren, Jun Lan, Xiaohui Ju, Mingli Gong

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

https://orcid.org/0000-0002-7290-0935

⨯
Jun Lan ,

Contributed equally to this work with: Wenlin Ren, Jun Lan, Xiaohui Ju, Mingli Gong

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China
⨯
Xiaohui Ju ,

Contributed equally to this work with: Wenlin Ren, Jun Lan, Xiaohui Ju, Mingli Gong

Roles Data curation, Formal analysis, Methodology

Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

https://orcid.org/0000-0002-9552-0222

⨯
Mingli Gong ,

Contributed equally to this work with: Wenlin Ren, Jun Lan, Xiaohui Ju, Mingli Gong

Roles Investigation

Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China
⨯
Quanxin Long,

Roles Methodology, Resources

Affiliation Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China

https://orcid.org/0000-0003-1857-2798

⨯
Zihui Zhu,

Roles Investigation

Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China
⨯
Yanying Yu,

Roles Investigation

Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China
⨯
Jianping Wu,

Roles Investigation, Supervision, Writing – original draft

Affiliation Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China
⨯
Jin Zhong,

Roles Project administration, Writing – review & editing

Affiliation Unit of Viral Hepatitis, Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai, China
⨯
Rong Zhang,

Roles Investigation, Supervision

Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China
⨯
Shilong Fan,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft

Affiliation Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China

https://orcid.org/0000-0001-9272-2438

⨯
Guocai Zhong,

Roles Methodology, Resources, Writing – review & editing

Affiliations Shenzhen Bay Laboratory, Shenzhen, China, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
⨯
Ailong Huang,

Roles Resources, Supervision

Affiliation Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China

https://orcid.org/0000-0003-0148-7423

⨯
Xinquan Wang ,

Roles Data curation, Investigation, Methodology, Project administration, Software, Supervision, Writing – review & editing

* E-mail: xinquanwang@tsinghua.edu.cn (XW); qding@tsinghua.edu.cn (QD)

Affiliation Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China
⨯
Qiang Ding

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: xinquanwang@tsinghua.edu.cn (XW); qding@tsinghua.edu.cn (QD)

Affiliation Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

https://orcid.org/0000-0002-6226-869X

⨯

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

Wenlin Ren,
Jun Lan,
Xiaohui Ju,
Mingli Gong,
Quanxin Long,
Zihui Zhu,
Yanying Yu,
Jianping Wu,
Jin Zhong,
Rong Zhang

Published: November 8, 2021
https://doi.org/10.1371/journal.ppat.1010053

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