A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis

• Hongwei Gu ,

  Contributed equally to this work with: Hongwei Gu, Xuwang Cai

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America, Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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• Xuwang Cai ,

  Contributed equally to this work with: Hongwei Gu, Xuwang Cai

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

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• Xinyang Zhang,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Key Laboratory of Veterinary Public Health of Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Jie Luo,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America

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• Xiaoyang Zhang,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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• Xiao Hu,

  Roles Data curation, Software

  Affiliation Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America

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• Wentong Cai ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: caiwentong@caas.cn (WC); liganwu@iastate.edu (GL)

  Affiliation Key Laboratory of Veterinary Public Health of Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

  https://orcid.org/0000-0002-2282-302X

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• Ganwu Li

  Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: caiwentong@caas.cn (WC); liganwu@iastate.edu (GL)

  Affiliations Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States of America, Key Laboratory of Veterinary Public Health of Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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