Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins

• Hatim Thaker ,

  Contributed equally to this work with: Hatim Thaker, Jie Zhang

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-0373-4267

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• Jie Zhang ,

  Contributed equally to this work with: Hatim Thaker, Jie Zhang

  Roles Investigation, Methodology

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Shin-Ichiro Miyashita,

  Roles Investigation

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America, Faculty of Bioindustry, Tokyo University of Agriculture, Hokkaido, Japan

  https://orcid.org/0000-0002-4815-9323

  ⨯
• Vivian Cristofaro,

  Roles Investigation

  Affiliations Division of Urology, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• SunHyun Park,

  Roles Investigation

  Affiliation R&D Center for Advanced Pharmaceuticals & Evaluation, Korea Institute of Toxicology (KIT), Daejeon, Republic of Korea

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• Ali Hashemi Gheinani,

  Roles Investigation, Resources

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Maryrose P. Sullivan,

  Roles Investigation, Supervision

  Affiliations Division of Urology, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, United States of America, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-6731-415X

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• Rosalyn M. Adam,

  Roles Funding acquisition, Investigation, Supervision

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-0943-6236

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• Min Dong

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: min.dong@childrens.harvard.edu

  Affiliations Department of Urology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Microbiology, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-1744-7293

  ⨯