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Open Access
Peer-reviewed
Research Article
Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection
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Elisabet Bjanes,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Current address: Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America
Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Reyna Garcia Sillas,
Roles Investigation
Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Rina Matsuda,
Roles Formal analysis, Investigation
Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Benjamin Demarco,
Roles Investigation
Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland
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Timothée Fettrelet,
Roles Investigation
Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland
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Alexandra A. DeLaney,
Roles Investigation
Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Opher S. Kornfeld,
Roles Investigation
Affiliation Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, United States of America
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Bettina L. Lee,
Roles Investigation
Affiliation Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, United States of America
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Eric M. Rodríguez López,
Roles Investigation
Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Immunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Daniel Grubaugh,
Roles Investigation
Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Meghan A. Wynosky-Dolfi,
Roles Investigation
Current address: Immunology Research Unit, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Naomi H. Philip,
Roles Investigation
Current address: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Immunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Elise Krespan,
Roles Investigation, Resources
Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Center for Host Microbial Interactions, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Dorothy Tovar,
Roles Investigation
Current address: Department of Microbiology & Immunology, Stanford University School of Medicine, Palo Alto California, United States of America
Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Leonel Joannas,
Roles Resources, Supervision
Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, CRISPR/Cas9 Mouse Targeting Core, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
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Daniel P. Beiting,
Roles Resources
Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Center for Host Microbial Interactions, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Jorge Henao-Mejia,
Roles Funding acquisition, Resources, Supervision
Affiliations Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Brian C. Schaefer,
Roles Funding acquisition, Resources, Writing – review & editing
Affiliation Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America
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Kaiwen W. Chen,
Roles Supervision, Writing – review & editing
Current address: Immunology Programme and Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland
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Petr Broz,
Roles Resources, Supervision
Affiliation Department of Biochemistry, University of Lausanne, Epalinges, Vaud, Switzerland
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Igor E. Brodsky
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: ibrodsky@vet.upenn.edu
Affiliations Cell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Immunology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection
- Elisabet Bjanes,
- Reyna Garcia Sillas,
- Rina Matsuda,
- Benjamin Demarco,
- Timothée Fettrelet,
- Alexandra A. DeLaney,
- Opher S. Kornfeld,
- Bettina L. Lee,
- Eric M. Rodríguez López,
- Daniel Grubaugh
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- Published: October 14, 2021
- https://doi.org/10.1371/journal.ppat.1009967