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Open Access
Peer-reviewed
Research Article
Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus
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Henry Ma ,
Contributed equally to this work with: Henry Ma, Joseph R. Albe
Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing
Affiliations Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Joseph R. Albe ,
Contributed equally to this work with: Henry Ma, Joseph R. Albe
Roles Data curation, Investigation, Methodology, Writing – review & editing
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Theron Gilliland,
Roles Data curation, Investigation, Methodology
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Cynthia M. McMillen,
Roles Formal analysis, Investigation, Methodology, Writing – review & editing
Affiliations Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Christina L. Gardner,
Roles Investigation, Writing – review & editing
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Devin A. Boyles,
Roles Investigation
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Emily L. Cottle,
Roles Investigation
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Matthew D. Dunn,
Roles Investigation, Methodology
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Jeneveve D. Lundy,
Roles Investigation
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Noah Salama,
Roles Investigation
Affiliations Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Katherine J. O’Malley,
Roles Investigation
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Ivona Pandrea,
Roles Data curation, Formal analysis
Affiliations Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Tobias Teichert,
Roles Data curation, Investigation, Methodology
Affiliations Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Stacey Barrick,
Roles Data curation, Project administration, Resources, Supervision
Affiliation Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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William B. Klimstra ,
Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
¶‡ WBK, ALH, and DSR also contributed equally to this work as senior authors.
Affiliations Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Amy L. Hartman ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
¶‡ WBK, ALH, and DSR also contributed equally to this work as senior authors.
Affiliations Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Douglas S. Reed
Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: dsreed@pitt.edu
¶‡ WBK, ALH, and DSR also contributed equally to this work as senior authors.
Affiliations Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus
- Henry Ma,
- Joseph R. Albe,
- Theron Gilliland,
- Cynthia M. McMillen,
- Christina L. Gardner,
- Devin A. Boyles,
- Emily L. Cottle,
- Matthew D. Dunn,
- Jeneveve D. Lundy,
- Noah Salama
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- Published: June 13, 2022
- https://doi.org/10.1371/journal.ppat.1009946