Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands

Ben Nicholas; Alistair Bailey; Karl J. Staples; Tom Wilkinson; Tim Elliott; Paul Skipp

doi:10.1371/journal.ppat.1009894

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Open Access

Peer-reviewed

Research Article

Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands

Ben Nicholas ,

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bln1@soton.ac.uk

Affiliations Centre for Proteomic Research, Biological Sciences and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, Centre for Cancer Immunology and Institute for Life Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

https://orcid.org/0000-0003-1467-9643

⨯
Alistair Bailey,

Roles Data curation, Formal analysis, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliations Centre for Proteomic Research, Biological Sciences and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, Centre for Cancer Immunology and Institute for Life Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

https://orcid.org/0000-0003-0023-8679

⨯
Karl J. Staples,

Roles Resources, Writing – review & editing

Affiliation Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

https://orcid.org/0000-0003-3844-6457

⨯
Tom Wilkinson,

Roles Project administration, Resources, Supervision, Writing – review & editing

Affiliations Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, NIHR Southampton BRC, UHS NHS FT, Southampton, United Kingdom
⨯
Tim Elliott,

Roles Project administration, Supervision, Writing – review & editing

Affiliation Centre for Cancer Immunology and Institute for Life Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Paul Skipp

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Centre for Proteomic Research, Biological Sciences and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom
⨯

Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands

Ben Nicholas,
Alistair Bailey,
Karl J. Staples,
Tom Wilkinson,
Tim Elliott,
Paul Skipp

Published: January 20, 2022
https://doi.org/10.1371/journal.ppat.1009894
See the preprint

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Influenza
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Respiratory infections
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Nuclear matrix
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Influenza A virus
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Influenza viruses
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