Hepatitis C virus induces oxidation and degradation of apolipoprotein B to enhance lipid accumulation and promote viral production

Bei Wang; Yue Zhu; Congci Yu; Chongyang Zhang; Qing Tang; He Huang; Zhendong Zhao

doi:10.1371/journal.ppat.1009889

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Peer-reviewed

Research Article

Hepatitis C virus induces oxidation and degradation of apolipoprotein B to enhance lipid accumulation and promote viral production

Bei Wang ,

Contributed equally to this work with: Bei Wang, Yue Zhu

Roles Formal analysis, Investigation, Methodology

Affiliations NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Clinical Immunology Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Yue Zhu ,

Contributed equally to this work with: Bei Wang, Yue Zhu

Roles Formal analysis, Investigation, Methodology

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Congci Yu,

Roles Methodology

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Chongyang Zhang,

Roles Methodology

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Qing Tang,

Roles Methodology

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
He Huang ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft

* E-mail: huanghe@ipb.pumc.edu.cn

Affiliations NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Clinical Immunology Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

https://orcid.org/0000-0002-4887-2671

⨯
Zhendong Zhao †

† Deceased.

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliations NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Clinical Immunology Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯

Hepatitis C virus induces oxidation and degradation of apolipoprotein B to enhance lipid accumulation and promote viral production

Bei Wang,
Yue Zhu,
Congci Yu,
Chongyang Zhang,
Qing Tang,
He Huang,
Zhendong Zhao

Published: September 7, 2021
https://doi.org/10.1371/journal.ppat.1009889

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Proteasomes
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Lipids
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Immunoblotting
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Oxidation
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Immunoprecipitation
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Oxidative stress
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DAPI staining
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