EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes

Chenhe Su; Fang Lu; Samantha S. Soldan; R. Jason Lamontagne; Hsin-Yao Tang; Giorgia Napoletani; Paul J. Farrell; Italo Tempera; Andrew V. Kossenkov; Paul M. Lieberman

doi:10.1371/journal.ppat.1009834

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Open Access

Peer-reviewed

Research Article

EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes

Chenhe Su,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Fang Lu,

Roles Investigation, Methodology

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Samantha S. Soldan,

Roles Formal analysis, Investigation, Methodology

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0001-6263-519X

⨯
R. Jason Lamontagne,

Roles Formal analysis, Investigation, Methodology

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-9068-3348

⨯
Hsin-Yao Tang,

Roles Data curation, Formal analysis, Methodology, Visualization

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0003-1838-018X

⨯
Giorgia Napoletani,

Roles Investigation, Methodology

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Paul J. Farrell,

Roles Methodology, Resources

Affiliation Imperial College, London, United Kingdom

https://orcid.org/0000-0002-6754-9351

⨯
Italo Tempera,

Roles Formal analysis, Methodology, Resources

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0001-7893-2914

⨯
Andrew V. Kossenkov,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Paul M. Lieberman

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: lieberman@wistar.org

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0002-3935-9921

⨯

EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes

Chenhe Su,
Fang Lu,
Samantha S. Soldan,
R. Jason Lamontagne,
Hsin-Yao Tang,
Giorgia Napoletani,
Paul J. Farrell,
Italo Tempera,
Andrew V. Kossenkov,
Paul M. Lieberman

Published: August 5, 2021
https://doi.org/10.1371/journal.ppat.1009834

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B cells
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Gene regulation
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Gene expression
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