Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus

• Ana Camila Oliveira Souza ,

  Contributed equally to this work with: Ana Camila Oliveira Souza, Adela Martin-Vicente

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-9639-1207

  ⨯
• Adela Martin-Vicente ,

  Contributed equally to this work with: Ana Camila Oliveira Souza, Adela Martin-Vicente

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0003-0446-8906

  ⨯
• Ashley V. Nywening,

  Roles Investigation, Methodology

  Affiliation Integrated Program in Biomedical Sciences, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-4969-4192

  ⨯
• Wenbo Ge,

  Roles Investigation, Methodology

  Affiliation Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  ⨯
• David J. Lowes,

  Roles Investigation, Methodology

  Affiliation Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0003-0401-6790

  ⨯
• Brian M. Peters,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliations Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Department of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-0445-2077

  ⨯
• Jarrod R. Fortwendel

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft

  * E-mail: jfortwen@uthsc.edu

  Affiliations Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Department of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0003-2301-4272

  ⨯