Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens

Jin-Tao Zou; Hai-Ming Jing; Yue Yuan; Lang-Huan Lei; Zhi-Fu Chen; Qiang Gou; Qing-Shan Xiong; Xiao-Li Zhang; Zhuo Zhao; Xiao-Kai Zhang; Hao Zeng; Quan-Ming Zou; Jin-Yong Zhang

doi:10.1371/journal.ppat.1009752

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Open Access

Peer-reviewed

Research Article

Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens

Jin-Tao Zou,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Hai-Ming Jing,

Roles Formal analysis, Methodology, Project administration, Writing – original draft

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Yue Yuan,

Roles Formal analysis, Methodology, Project administration

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Lang-Huan Lei,

Roles Investigation, Methodology, Project administration

Affiliations National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China, Department of Critical Care Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, PR China
⨯
Zhi-Fu Chen,

Roles Investigation, Methodology

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Qiang Gou,

Roles Investigation, Methodology

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Qing-Shan Xiong,

Roles Methodology

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Xiao-Li Zhang,

Roles Methodology

Affiliation Department of Clinical Hematology, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Zhuo Zhao,

Roles Methodology

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Xiao-Kai Zhang,

Roles Methodology

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Hao Zeng,

Roles Project administration, Supervision

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Quan-Ming Zou ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: qmzou2007@163.com (Q-MZ); zhangjy198217@126.com (J-YZ)

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China
⨯
Jin-Yong Zhang

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: qmzou2007@163.com (Q-MZ); zhangjy198217@126.com (J-YZ)

Affiliation National Engineering Research Center of Immunological Products & Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, PR China

https://orcid.org/0000-0001-9622-5834

⨯

Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens

Jin-Tao Zou,
Hai-Ming Jing,
Yue Yuan,
Lang-Huan Lei,
Zhi-Fu Chen,
Qiang Gou,
Qing-Shan Xiong,
Xiao-Li Zhang,
Zhuo Zhao,
Xiao-Kai Zhang

Published: July 21, 2021
https://doi.org/10.1371/journal.ppat.1009752

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