Impaired function and delayed regeneration of dendritic cells in COVID-19

Elena Winheim; Linus Rinke; Konstantin Lutz; Anna Reischer; Alexandra Leutbecher; Lina Wolfram; Lisa Rausch; Jan Kranich; Paul R. Wratil; Johanna E. Huber; Dirk Baumjohann; Simon Rothenfusser; Benjamin Schubert; Anne Hilgendorff; Johannes C. Hellmuth; Clemens Scherer; Maximilian Muenchhoff; Michael von Bergwelt-Baildon; Konstantin Stark; Tobias Straub; Thomas Brocker; Oliver T. Keppler; Marion Subklewe; Anne B. Krug

doi:10.1371/journal.ppat.1009742

Loading metrics

Open Access

Peer-reviewed

Research Article

Impaired function and delayed regeneration of dendritic cells in COVID-19

Elena Winheim,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany

https://orcid.org/0000-0002-0364-662X

⨯
Linus Rinke,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany

https://orcid.org/0000-0002-7563-7116

⨯
Konstantin Lutz,

Roles Formal analysis, Visualization

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany

https://orcid.org/0000-0002-6263-467X

⨯
Anna Reischer,

Roles Investigation, Methodology

Affiliations Department of Medicine III, University Hospital, LMU Munich; Munich, Germany, Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich; Munich, Germany
⨯
Alexandra Leutbecher,

Roles Investigation, Methodology

Affiliations Department of Medicine III, University Hospital, LMU Munich; Munich, Germany, Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich; Munich, Germany
⨯
Lina Wolfram,

Roles Investigation

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany
⨯
Lisa Rausch,

Roles Investigation

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany
⨯
Jan Kranich,

Roles Investigation

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany

https://orcid.org/0000-0002-9928-4132

⨯
Paul R. Wratil,

Roles Formal analysis, Investigation, Methodology

Affiliations Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine & Gene Center, Virology, National Reference Center for Retroviruses, LMU Munich; Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Germany
⨯
Johanna E. Huber,

Roles Methodology

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany
⨯
Dirk Baumjohann,

Roles Methodology, Writing – review & editing

Affiliations Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany, Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Bonn, Germany

https://orcid.org/0000-0001-8385-8288

⨯
Simon Rothenfusser,

Roles Methodology, Writing – review & editing

Affiliations Division of Clinical Pharmacology, University Hospital, LMU Munich; Munich, Germany, Unit Clinical Pharmacology (EKLiP), Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany

https://orcid.org/0000-0003-1151-7614

⨯
Benjamin Schubert,

Roles Formal analysis

Affiliations Institute of Computational Biology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Department of Mathematics, Technical University of Munich, Garching, Germany
⨯
Anne Hilgendorff,

Roles Funding acquisition

Affiliations Institute for Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Germany, Center for Comprehensive Developmental Care (CDeCLMU), Dr. Von Haunersche Children’s Hospital, University Hospital LMU Munich; Munich, Germany
⨯
Johannes C. Hellmuth,

Roles Resources, Supervision

Affiliations Department of Medicine III, University Hospital, LMU Munich; Munich, Germany, COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich; Munich, Germany
⨯
Clemens Scherer,

Roles Formal analysis, Resources, Supervision

Affiliations COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich; Munich, Germany, Department of Medicine I, University Hospital, LMU Munich; Munich, Germany

https://orcid.org/0000-0003-2816-6793

⨯
Maximilian Muenchhoff,

Roles Resources, Supervision

Affiliations Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine & Gene Center, Virology, National Reference Center for Retroviruses, LMU Munich; Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Germany, COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich; Munich, Germany

https://orcid.org/0000-0001-7016-0470

⨯
Michael von Bergwelt-Baildon,

Roles Funding acquisition, Resources, Supervision

Affiliations Department of Medicine III, University Hospital, LMU Munich; Munich, Germany, COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich; Munich, Germany, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ); Heidelberg, Germany
⨯
Konstantin Stark,

Roles Resources

Affiliations COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich; Munich, Germany, Department of Medicine I, University Hospital, LMU Munich; Munich, Germany
⨯
Tobias Straub,

Roles Formal analysis, Visualization

Affiliation Core Facility Bioinformatics, Biomedical Center, LMU Munich; Munich, Germany

https://orcid.org/0000-0002-0547-0453

⨯
Thomas Brocker,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany
⨯
Oliver T. Keppler,

Roles Funding acquisition, Supervision

Affiliations Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine & Gene Center, Virology, National Reference Center for Retroviruses, LMU Munich; Munich, Germany, German Center for Infection Research (DZIF), partner site Munich, Germany

https://orcid.org/0000-0002-1384-8946

⨯
Marion Subklewe,

Roles Conceptualization, Funding acquisition, Supervision

Affiliations Department of Medicine III, University Hospital, LMU Munich; Munich, Germany, Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich; Munich, Germany
⨯
[ ... ],
Anne B. Krug

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: anne.krug@med.uni-muenchen.de

Affiliation Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich; Munich, Germany

https://orcid.org/0000-0002-9556-7207

⨯
[ view all ]
[ view less ]

Impaired function and delayed regeneration of dendritic cells in COVID-19

Elena Winheim,
Linus Rinke,
Konstantin Lutz,
Anna Reischer,
Alexandra Leutbecher,
Lina Wolfram,
Lisa Rausch,
Jan Kranich,
Paul R. Wratil,
Johanna E. Huber

Published: October 6, 2021
https://doi.org/10.1371/journal.ppat.1009742

Reader Comments (2)

Post a new comment on this article

1 Response

19 Jul 2023
11:06 GMT
Most Recent

More information on cohorts Posted by dsmith414 on 01 Feb 2023 at 04:36 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

COVID 19
Is the Subject Area "COVID 19" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Virus testing
Is the Subject Area "Virus testing" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
T helper cells
Is the Subject Area "T helper cells" applicable to this article?

Thanks for your feedback.