PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi

• Ashley M. Groshong,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Laboratory of Bacteriology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

  Affiliations Department of Medicine, UConn Health, Farmington, Connecticut, United States of America, Department of Pediatrics, UConn Health, Farmington, Connecticut, United States of America

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• André A. Grassmann,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Medicine, UConn Health, Farmington, Connecticut, United States of America

  https://orcid.org/0000-0002-3910-2165

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• Amit Luthra,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Department of Medicine, UConn Health, Farmington, Connecticut, United States of America

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• Melissa A. McLain,

  Roles Data curation, Visualization

  Affiliation Department of Medicine, UConn Health, Farmington, Connecticut, United States of America

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• Anthony A. Provatas,

  Roles Data curation, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Environmental Sciences and Engineering, University of Connecticut, Storrs, Connecticut, United States of America

  https://orcid.org/0000-0001-9091-3740

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• Justin D. Radolf,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Medicine, UConn Health, Farmington, Connecticut, United States of America, Department of Pediatrics, UConn Health, Farmington, Connecticut, United States of America, Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, United States of America, Department of Genetics and Genome Science, UConn Health, Farmington, Connecticut, United States of America, Department of Immunology, UConn Health, Farmington, Connecticut, United States of America

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• Melissa J. Caimano

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Mcaima@uchc.edu

  Affiliations Department of Medicine, UConn Health, Farmington, Connecticut, United States of America, Department of Pediatrics, UConn Health, Farmington, Connecticut, United States of America, Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, United States of America

  https://orcid.org/0000-0003-1170-4102

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