Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication

• Nawar Naseer ,

  Contributed equally to this work with: Nawar Naseer, Marisa S. Egan, Valeria M. Reyes Ruiz

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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• Marisa S. Egan ,

  Contributed equally to this work with: Nawar Naseer, Marisa S. Egan, Valeria M. Reyes Ruiz

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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• Valeria M. Reyes Ruiz ,

  Contributed equally to this work with: Nawar Naseer, Marisa S. Egan, Valeria M. Reyes Ruiz

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee

  Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

  https://orcid.org/0000-0002-4824-9898

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• William P. Scott,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon

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• Emma N. Hunter,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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• Tabitha Demissie,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

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• Isabella Rauch,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon

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• Igor E. Brodsky,

  Roles Conceptualization, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania

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• Sunny Shin

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sunshin@pennmedicine.upenn.edu

  Affiliation Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania

  https://orcid.org/0000-0001-5214-9577

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