Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm

• Leonardo M. Cortez ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lcortez@ualberta.ca (LMC); valerie.sim@ualberta.ca (VLS)

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada

  https://orcid.org/0000-0003-4080-8728

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• Satish K. Nemani,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada

  https://orcid.org/0000-0003-0505-3577

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• Camilo Duque Velásquez,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Aishwarya Sriraman,

  Roles Investigation

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  https://orcid.org/0000-0001-6618-4672

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• YongLiang Wang,

  Roles Investigation

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

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• Holger Wille,

  Roles Resources, Validation, Visualization, Writing – review & editing

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

  https://orcid.org/0000-0001-5102-8706

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• Debbie McKenzie,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada

  https://orcid.org/0000-0002-9291-6977

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• Valerie L. Sim

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lcortez@ualberta.ca (LMC); valerie.sim@ualberta.ca (VLS)

  Affiliations Centre for Prions and Protein Folding Diseases, Edmonton, Alberta, Canada, Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta, Canada

  https://orcid.org/0000-0002-0088-8666

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