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Open Access
Peer-reviewed
Research Article
H2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host cell invasion
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Juliana Nunes Rosón,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil, Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina–UNIFESP, São Paulo, Brazil
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Marcela de Oliveira Vitarelli,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Héllida Marina Costa-Silva,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Kamille Schmitt Pereira,
Roles Formal analysis, Investigation
Affiliations Department of Bioprocesses and Biotechnology, Universidade Federal do Paraná, Curitiba, Brazil, Laboratory of Molecular and Systems Biology of Trypanosomatids, Carlos Chagas Institute, FIOCRUZ, Curitiba, Brazil
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David da Silva Pires,
Roles Data curation, Investigation, Software
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Leticia de Sousa Lopes,
Roles Formal analysis, Investigation
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Barbara Cordeiro,
Roles Formal analysis, Investigation
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Amelie J. Kraus,
Roles Formal analysis, Investigation
Affiliations Division of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität in Munich, Munich, Germany, Biomedical Center, Division of Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universitäat in Munch, Munich, Germany
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Karin Navarro Tozzi Cruz,
Roles Investigation
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Simone Guedes Calderano,
Roles Conceptualization, Formal analysis, Investigation, Supervision
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Stenio Perdigão Fragoso,
Roles Formal analysis, Investigation, Methodology, Supervision
Affiliations Department of Bioprocesses and Biotechnology, Universidade Federal do Paraná, Curitiba, Brazil, Laboratory of Molecular and Systems Biology of Trypanosomatids, Carlos Chagas Institute, FIOCRUZ, Curitiba, Brazil
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T. Nicolai Siegel,
Roles Data curation, Investigation, Methodology, Supervision, Writing – review & editing
Affiliations Division of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität in Munich, Munich, Germany, Biomedical Center, Division of Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universitäat in Munch, Munich, Germany
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Maria Carolina Elias,
Roles Conceptualization, Data curation, Supervision, Writing – original draft, Writing – review & editing
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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Julia Pinheiro Chagas da Cunha
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: julia.cunha@butantan.gov.br
Affiliations Laboratory of Cell Cycle, Butantan Institute, São Paulo, Brazil, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo, Brazil
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H2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host cell invasion
- Juliana Nunes Rosón,
- Marcela de Oliveira Vitarelli,
- Héllida Marina Costa-Silva,
- Kamille Schmitt Pereira,
- David da Silva Pires,
- Leticia de Sousa Lopes,
- Barbara Cordeiro,
- Amelie J. Kraus,
- Karin Navarro Tozzi Cruz,
- Simone Guedes Calderano
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- Published: February 18, 2022
- https://doi.org/10.1371/journal.ppat.1009694